These are the ingredients of ActiFlex 4000 and their benefits. I strongly believe these ingredients add additional years and quality of health to our dogs lives.
This supplement is for large breed adult dogs over 1 yr., medium breeds over 3 yrs.,
small breeds over 5 yrs. Suggested amounts listed at bottom of page.
Guaranteed Analysis Per ounce:
Glucosamine Sulfate 8000 mg
Chondroitin Sulfate 4000 mg
Type II Collagen 3000 mg
MSM 3000 mg
Ester C 1000 mg
Perna Canaliculus 1000 mg
Yucca 150 mg
SOD 150 mg (estimated)
Boswellia Serrata 150 mg (estimated)
Hyaluronic Acid 125 mg
Bioperine 100 mg
Glucosamine is found in high concentrations in the joints. It has been theorized
that glucosamine stimulates the formation of cartilage that is essential for
joint repair. In animal models, oral glucosamine sulfate has a beneficial effect
on inflammation, mechanical arthritis, and immunological-reactive arthritis.
Glucosamine is primarily used to treat osteoarthritis. Research indicates that
glucosamine is as effective as low doses of non steroidal anti-inflammatories
such as ibuprofen. It appears to relieve pain and improve movement. It also
slows the progression of the disease and protect joints from further damage. In
some studies, x-rays have shown that glucosamine prevents progressive damage to
Glucosamine appears to be safe for people and many animals. Glucosamine is
sometimes used in combination with chondroitin sulfate as a treatment for
Chondroitin sulfate is also found in cartilage. Chondroitin sulfate reportedly
maintains the viscosity in joints, stimulates cartilage repair mechanisms, and
inhibits enzymes that break down cartilage
Chondroitin sulfate exists naturally in your cartilage. It's thought to
draw fluid into the tissue to give our cartilage more elasticity and to slow
cartilage breakdown by protecting it from destructive enzymes. As a supplement,
it is exclusively derived from cattle sources and is often taken along with
Glucosamine to assist with maintaining joint health. The combined use is known
to produce a "synergistic" effect. It's been prescribed for pain relief
in osteoarthritis in some parts of Europe where it is a prescription drug for
decades. If glucosamine is your #1 joint friend, chondroitin is #2.
Although Chondroitin alone hasn't been proven to help with or reverse cartilage
loss, in some studies it appeared to help improve function and ease pain. In one
placebo-controlled study, joint narrowing in the knee became stabilized in
patients who were put on Chondroitin supplement. Another controlled
study looked at osteoarthritis of the finger joints for a period of three years.
Among the group that took chondroitin, there was a significant decrease in the
number of patients with new erosions in their finger joints.
Chondroitin in fact is a glycosaminoglycan (think long chains of glucosamine)
that is concentrated in joint cartilage. Like glucosamine, chondroitin helps
produce substances needed for the formation of connective tissue. In addition
chondroitin (unlike glucosamine) may also have the ability to protect existing
cartilage from prematurely breaking down by inhibiting cartilage-destroying
How Does Chondroitin Work?
Chondroitin sulfates provide the structural components of joint cartilage,
inhibit some free radical enzymes that degrade joint cartilage and collagen, and
facilitate the entry of glucosamine into the joints. Like glucosamine,
chondroitin sulfate attracts water into the cartilage matrix and stimulates the
production of cartilage. It also appears to have the ability to prevent enzymes
from dissolving cartilage. Recent studies have shown extremely good results from
long-term use of chondroitin sulfate (alone and in combination with glucosamine)
in increasing range of motion and overall joint health. Both glucosamine and
chondroitin should be used together, however, to produce the best results.
Many animals that have hip dysplasia benefit from being on glucosamine and
chondroitin because it helps heal the cartilage and reduce the pain involved
with this disease
Type II Collagen
Patients suffering from arthritis, experience a selective destruction of
collagen type II in the cartilage within their joints. Type II collagen is the
major protein found in cartilage. It as the "glue" that holds together the
cartilage and it helps provide elasticity within the joints. In addition,
cartilage is able to heal itself because of the mucopolysaccharides are
contained in Type II collagen.
Recent clinical trials involving patients with severe, active rheumatoid
arthritis showed a decrease in the number of swollen joints and tender joints
among subjects using type II collagen for 3 months. Type II collagen is non
toxic and considered a safe alternative to NSAIDS.
Collagen type II also contains proteoglycans that inhibit blood vessel formation
in joints and reduce enzyme attacks on the cartilage itself. Thus, there is a
rejuvenation of the cartilage producing cells and a decrease in the destructive
biochemistry of the joint. Additionally, many of these proteoglycans found in
collagen type II support the lubricating fluid of the joint called the synovial
fluid. These proteoglycans increase the thickness and lubricating effectiveness
of this fluid.
Nature's secret for pain and inflammation relief are MSM nutritional sulfurs
that lower pain and inflammation, while increasing mobility. MSM sulfur also
known as methylsulfonylmethane is a natural, effective and economical way to
deal with pain and inflammation.
Veterinarians have been using MSM for over 35 years to relieve dog and cat
chronic pain and inflammation from arthritis or hip dysplasia in animals. MSM
Sulfur supplements are essential to your dog or cat's health.
The body is made up of 1/3 sulfur by weight, the body uses this sulfur on a daily basis in order to heal or repair itself. MSM
Sulfur is vital to the production of energy in the body. It is an essential
ingredient of the protein necessary for collagen synthesis. Collagen can not be
produced in the body unless sulfur is also present.
MSM is one of nature's richest sources of sulfur. Sulfur deficiency can result in
the body being unable to repair or replace damaged tissue adequately, resulting
in production of abnormal cells that can lead to illness or even cancer.
Although sulfur is found in both plants and animals, due to our over processing
and long storage of our food sources, it is difficult for the body to maintain
the proper amount of sulfur needed without supplementation.
MSM is one of the most effective nutritional supplements in alternative medicine
for providing fast pain and inflammation relief. MSM provides pain and
inflammation relief for Arthritis Pain, Chronic pain from Fibromyalgia and Lower
MSM can reduce pain and inflammation by 50% or MORE without the risk of side
effects or drug interactions. MSM is now recognized and recommended by numerous
Doctors, Physical Therapists, Chiropractors and Dentists due to its
effectiveness at relieving joint pain and inflammation.
Ester C is an advanced 'body-ready' form of vitamin C that is easily digested
and quickly absorbed by the body. This blend of non-acidic mineral ascorbate and
vitamin C metabolites synergistically speeds intracellular absorption and
maximizes the utilization of vitamin C in the body. Vitamin C is one of the
body's best known and most important antioxidants, and has a variety of
beneficial effects. It is critical to immune function and plays an important
role in the formation of collagen & the protein of connective tissue,
cartilage and tendons. It is a powerful antioxidant and protects other vitamins
such as E and A from oxidation. It also promotes the absorption of iron, calcium
and magnesium in the body and works with the B vitamins to promote the proper
utilization of proteins. This important water-soluble vitamin cannot be
manufactured by the body so must be regularly obtained from the diet.
Maintain optimum vitamin C levels with Ester C a form of vitamin C that
can be easily absorbed and used efficiently by the body. Ester C delivers:
A highly bioavailable form of vitamin C The ability to increase intracellular
vitamin C levels more efficiently than other forms of ascorbic acid
A buffered form of vitamin C for easier digestion*
Perna contains a natural mineral balance. It is made up of 61% protein, 13%
carbohydrates, 12% glycosaminoglycans (GAGs), 5% lipids (including
eicosatetraenoic acids, or ETAs), 5% minerals, and 4% water. Perna mussel also
contains glucosamine, a GAG precursor and one of the building blocks of
cartilage. Glucosamine, GAGs (unbranched chains of complex sugars) and ETAs (a
type of Omega-3 fatty acids) are the compounds in the mussel believed to
contribute to its beneficial effects. ETAs are the key ingredients that help in
the anti-inflammatory activity and thereby the reduction of joint pain. GAGs are
the main components of cartilage and the synovial fluid found in joints.
GAGs increase the lubrication of the joint and increase water uptake into the
cartilage. This water uptake, which decreases with age, is necessary for the
lubrication and shock absorption of the joints. There are nine classes of GAGs,
five of which are related to connective tissue. Two of these five are
chondroitins, which make up the basic substance of both bone and cartilage. GAGs
provide flexibility, elasticity, and strength to cartilage.
Published reports are consistent in their findings that Perna mussel produces an
anti-inflammatory response. A Clemson University study found that Perna was
effective in reducing the onset of rheumatoid arthritis as well as reversing it
in mice and rats. Out of eighteen test animals with arthritis that were fed
Perna mussel, only three developed arthritis compared to 10 out of 15 in the
control group. Another study found that the green-lipped mussel was effective in
reducing pain, swelling, and stiffness in 60 human patients with rheumatoid
arthritis and osteoarthritis. A French study using 53 patients suffering from
osteoarthritis in the knee reported that the Perna extract was "well tolerated
by the participants with no adverse conditions reported."
Ongoing research in both humans and animals continue to show that the use of
green-lipped mussel is, when used as directed, an effective supplement for the
management of osteoarthritis and rheumatoid arthritis. Perna mussel has been
successful in managing degenerative joint diseases and arthritis in both human
and veterinary health fields: it contains natural anti-inflammatory agents and
many essential building blocks needed to rebuild the necessary components in
joints. It also is reported to reduce pain, swelling, and inflammation
associated with arthritis and improve joint mobility.
The primary medical use of yucca is to treat arthritis and joint pain and
inflammation. Native Americans used sap from the leaves in poultices or baths to
treat skin lesions, sprains, inflammation, and bleeding. Constituents of the
yucca are used today to treat people with osteoarthritis and rheumatoid
arthritis . The plant's medical properties are found in saponins, precursors of
cortisone, which prevent the release of toxins from the intestines that restrict
normal cartilage formation. Saponins are produced naturally in the body by the
adrenal glands. It is believed yucca works best for arthritis when taken over an
extended period of time.
S.O.D. or superoxide dismutase, is the general name given to a class of enzymes
which make up an important antioxidant system in the body. They neutralize free
radicals (harmful by products of cellular respiration), particularly the
superoxide radical the most common free radical in the body.
The enzyme superoxide dismutase (SOD) catalyzes the dismutation of superoxide
into oxygen and hydrogen peroxide. As such, it is an important antioxidant
defense in nearly all cells exposed to oxygen.
Superoxide is one of the main reactive oxygen species in the cell and as such,
SOD serves a key antioxidant role. SOD is an enzyme widely distributed in the
body, which destroys superoxide radicals. These free radicals have been linked
with cancer and degenerative diseases. Some believe that they have insufficient
SOD to deal with the large amounts of free radicals and consequently, take
supplements of SOD to protect the body against the adverse effects of the
Boswellia has anti-carcinogenic, anti-tumor and blood lipid lowering activities.
Relieves muscle & joint pain
Effective in easing pain associated with Rheaumatoid Arthritis and Osteoarthritis
Lessens morning stiffness and increases joint mobility
Reduces aching and stiffness, especially in the lower back
Helps to prevent the breakdown of connective tissue.
Hyaluronic acid plays an important role in tissue dehydration, lubrication and
cellular function. It is produced in the body naturally, however, over time, as
with all vitamins and nutrients in the body, the synthesis of Hyaluronic Acid
diminishes. In fact, the half-life of Hyaluronic Acid in the cartilage is 2-3
weeks, and only 1 day in the skin.
When the decline in hyaluronic acid synthesis begins to happen, you may
experience joint discomfort, wrinkles and a tendency to get sick frequently.
When there is a constant supply of Hyaluronic Acid running through your body,
here are some of the benefits you will experience:
Hyaluronic acid provides a cushion effect between the joints. You are
able to move easier and feel less pain. Hyaluronic acid provides a
"reservoir of water" within the skin. Suddenly, you find you have more
elasticity in your skin and it feels softer. Hyaluronic acid reduces
bacterial infections. Hyaluronic Acid has been found to raise the white cell
count in your bloodstream.
How does Bioperine work?
The metabolic process that generates energy at the cellular level in the human
body is called thermogenesis. Though thermogenesis has been identified as a key
factor in maintaining weight loss, it has also been identified as playing an
integral role in utilizing the daily food and nutrients that the human body
consume s. It sets in motion the mechanisms that lead to digestion and
subsequent gastrointestinal absorption. Piperine, in the patented form of
Bioperine enhances the body's natural thermogenic activity - hence the
This enhancement may be explained as a means of increasing the thermal energy
sufficient to "power up" the mechanism related to thermogenesis. This in turn
results in increased metabolic processes that creates a "demand" for "supply" of
a broad range of nutrients that contribute to metabolism, i.e. vitamins,
minerals, herbals, amino acids, etc. It is as if Bioperine activates a
metabolic paddle wheel, of sorts, that selectively provides a more efficient
mode of nutrient transportation into the blood.
The Advantages of Bioperin
Bioperine is the only product sourced out of piperine to obtain a
patented status for its ability to increase the bioavailability of nutritional
compounds. Secondly, it is the only source from piperine to have undergone
clinical studies in the U.S. to substantiate its safety and efficacy for
While this link offers a canine formula, I prefer the equine formula. FYI... I have confirmed feeding the
equine formula to dogs with a positive response from the manufacturer. The measures given below are
approximated for average dogs in good health.
My dogs love the taste and readily eat it on their food.
There is a measuring cap on the 1 quart container and I give my great danes (large, giant breeds), on average,
approximately 1/4 ounce twice weekly to start for ages 1-2 yrs.
1/2 ounce two - three times week from ages 2-4 yrs. 1/2 - 3/4 ounce three times week from ages 4-6 yrs.
1/2 - 1 ounce three - four times weekly from ages 6-9 yrs. 3/4 - 1 ounce daily from ages 9 to infinity!
I have been extremely blessed over the last 36 years not to have lost a great dane under the age of 10 1/2 yrs old
and several have lived to be over 12 - 13 yrs. I have never had to make the decision to help my danes cross over, they have all passed on naturally of old age and all have had mobility right up until they left this earth. I have truly been blessed in this regard.
My standard poodles (medium breeds) recieve, on average, approximately 1/4 ounce weekly starting at age 2 yrs. 1/4 ounce
twice weekly from ages 3-5. 1/2 ounce twice weekly from ages 5-6. 1/2 ounce three times weekly from 6-8.
1/2 ounce 4 times weekly from age 8-10. I now feed 1/2 ounce daily after age 10, which Honey and my Nina
turned in May and June of 2008.
Small breeds over the age of 5 yrs., I start with 1/8 to 1/4 ounce twice week from 5-7, 1/4 ounce two - three times
week from 7-9, 1/4 ounce every other day to daily, depending on needs of individual, from 10 yrs to infinity!
My dachshund, BB, adopted at 12 yrs old (owner told me her age) lived to be over 20 yrs old. What a joy!
Buy one gallon, get 1quart free!